p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown useful in the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be highly sensitive and specific for detecting lung squamous cell carcinomas of the breast. p63 staining can be identified in myoepithelial cells of normal ducts. The expression of p504S protein is found in prostatic adenocarcinoma. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia
(PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
p63/p504s Cocktail – RUO (Europe)
Description
Additional information
Catalog No. | PDRMP001R |
---|---|
Clone | DBR 16.1 / Polyclonal |
Species | Rabbit |
Isotype | IgG / N/A |
Immunogen | Recombinant human p63 protein fragment + Synthetic human AMACR peptide |
Cellular Localization | Nuclear and Cytoplasmic |
Positive Control Tissue | Prostate |
Pretreatment | EDTA Buffer pH 8.0 |
Incubation & Temperature | 30 min @ RT |
Intended Use | RUO (Europe) |
Detection System | PolyVue™ Plus – Two Step Detection System or Montage PolyVue Plus™ Auto Detection System for Montage 360 System |
Description/Type | Rabbit Mono/Polyclonal Antibody |
Format | This product is supplied as a purified immunoglobulin and contains sodium azide as a preservative. |
Reviews (0)
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.